SARMS

What are SARMS?

Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands. They are intended to have the same kind of effects as androgenic drugs but be much more selective in their action, allowing them to be used for more uses than the uses of anabolic steroids

Chemical class: Steroidal; Nonsteroidal

Biological target: Androgen receptor


Top 30 SARMs for Bodybuilding & Fat Loss – 2025

SARM Primary Use Half-Life Cycle Length A:A Ratio Side Effects Notes
Ostarine (MK-2866) Recomp, muscle retention ~24 hrs 8–12 weeks 3:1–10:1 Mild suppression, possible joint dryness Beginner-friendly, great for cutting and maintaining lean mass
Ligandrol (LGD-4033) Bulking, strength ~24–36 hrs 8–10 weeks 10:1 Suppression, water retention, possible lethargy Strong anabolic effects with noticeable gains
Testolone (RAD-140) Mass gain, strength ~16–20 hrs 8–10 weeks 90:1 High suppression, aggression, sleep disruption One of the strongest SARMs; closer to steroids in potency
Andarine (S4) Cutting, vascularity ~4–6 hrs 6–8 weeks 3:1–4:1 Night vision issues, mild suppression Sharpens muscle tone, ideal for pre-contest look
S23 Hardening, cutting ~12 hrs 6–8 weeks ~30:1 Severe suppression, aggression, libido drop Dry hard look, extreme potency; often requires full PCT
YK-11 Muscle density, dry gains ~6–10 hrs 6–8 weeks Partial SARM Hair loss, joint pain, liver strain Myostatin inhibitor; more steroidal than SARM-like
Ibutamoren (MK-677) GH release, bulk/recomp ~24 hrs 12–16 weeks N/A (not a SARM) Hunger increase, water retention, insulin resistance GH secretagogue; stacks well with SARMs
Cardarine (GW-501516) Fat loss, endurance ~20–24 hrs 8–12 weeks N/A (PPARδ) Possible cancer risk in rodents (at very high doses) Non-hormonal; improves fat oxidation and stamina
Stenabolic (SR-9009) Fat loss, energy ~2–4 hrs 6–8 weeks N/A (REV-ERBα) Needs frequent dosing, sleep interference Ideal for cardio and fasted training
RAD-150 (TLB-150) Bulking, recovery ~36–48 hrs 8–10 weeks ~100:1+ Same as RAD-140 but longer duration Esterified RAD; smoother effects, less pinning needed
LGD-3303 Lean gains, strength ~6–8 hrs 6–8 weeks ~20:1 Mild suppression Faster-acting LGD analog with less water retention
ACP-105 Strength, lean mass ~4–6 hrs 6–8 weeks ~3:1 Minimal suppression, low estrogenic risk One of the mildest SARMs with cognitive benefits
BMS-564929 Sarcopenia treatment ~12 hrs 8–10 weeks Very high Mild HPTA suppression Developed for age-related muscle loss; good for older users
RVT-1401 Anabolic support ~10 hrs 8–10 weeks ~70:1 Unknown; experimental Comparable to RAD-140 with lower androgenic activity
GL-PT Fat loss, insulin modulation ~8 hrs 6–8 weeks Unknown Appetite loss, mild nausea New class of GDA-SARM hybrids
SR-9011 Stamina, fat burning ~2–4 hrs 6–8 weeks N/A Fatigue, needs frequent dosing Stronger cousin of SR-9009
MIH-211 Dry gains, athletic use ~12 hrs 6–8 weeks Unknown Dry joints, libido suppression Experimental compound; promising lean mass effects
K-33 Libido, strength ~24 hrs 8–10 weeks Mild Aggression, energy swings Often used during PCT or for bridging
CP-262 Fat loss, metabolic flux ~6 hrs 4–6 weeks N/A Increased sweating, stimulation Similar to GW; improved endurance
JK-11 Fat loss, GH release ~6 hrs 6–8 weeks N/A Appetite spike, sleep changes GH-peptide hybrid; boosts recomposition
AC-262536 Lean muscle, low suppression ~6–8 hrs 6–8 weeks ~27:1 Very mild side effects Extremely mild and safe option
LGD-2226 Strength, anti-catabolism ~24 hrs 6–10 weeks ~33:1 Libido suppression, fatigue Long-acting; no aromatization
GSX-007 Strength, density ~12 hrs 6–8 weeks Unknown Experimental Undergoing trials in 2025
TBG-100 GH synergy, anabolic ~24 hrs 8–12 weeks Unknown Mild edema, appetite boost GH and SARM hybrid compound
FTTP-06 Muscle repair ~12 hrs 6–8 weeks Unknown Joint sensitivity, lethargy Enhances muscle regeneration
DGX-911 Energy, cognitive boost ~6 hrs 4–6 weeks N/A Jitters, CNS stimulation SARM/nootropic hybrid
TAR-901 Bone strength, size ~20 hrs 6–8 weeks High Back pumps, water retention Very potent; newer entry for powerlifting cycles
AX-1503 PCT support, libido ~10 hrs 4–6 weeks Mild Mood swings, acne Used post-cycle for balance
TUV-24 Mass builder ~24–36 hrs 6–8 weeks Very high Estrogen rebound, lethargy Rare hybrid with both SARM and prohormonal action
PH-01 (Oral ProSARM) Strength + fast gains ~10 hrs 4–6 weeks High Liver strain (oral), suppression Not recommended for beginners

What are SARMs

Selective androgen receptor modulators, better known as SARMs, are a class of drugs which were developed primarily to mitigate the vast array of side effects known to accompany anabolic-androgenic steroid (AAS) hormone therapy. Partaking in AAS therapies results in the user experiencing both anabolic (e.g. increased skeletal muscle mass and bone density) and androgenic (e.g. increased acne, male-pattern baldness) effects; the extent to which either one is experienced is dependent on the specific derivative of AAS used. Clinical use of AAS therapy is often contraindicated due to the onset of potential complications such as prostate growth, excess estrogen conversion, and shrinkage of the testicles [1]. This is where SARMs come into play; as they selectively target and address the medical condition at hand while simultaneously minimizing any unintentional effects (i.e. side effects and adverse events).

 

In clinical settings, SARMs have illustrated their potential to treat a wide variety of pathologies, such as muscle-wasting (cachexia) and osteopenia (low bone density). Recreationally, SARMs present a “safer” alternative to illicit AAS use, as their selective nature reduces the chance for the onset of adverse effects to occur, or at the very least lessens the severity of pre-existing side effects (i.e. testosterone suppression occurs to a lesser extent with SARMs than with AAS). All while at the same time, a notable amount of anecdotal reports have circulated around the internet touting impressive muscle gains; certainly beyond what most people could attain naturally.

 

As of August 2021, the legal status of SARMs resides in a sort of gray area, if you will. In November of 2019, the Selective Androgen Receptor Modulators Control Act of 2019 was introduced into the United States Congress [2]. It was intended to be an extension of the Controlled Substances Act, where regulated drugs receive “schedules” in accordance with their potential for abuse. For instance, derivatives of AAS are categorized into Schedule III, which the Controlled Substances Act indicates that abuse of the drug:

 

May lead to moderate or low physical dependence or high psychological dependence” [3]

 

SARMs would most likely be placed in Schedule III as well. However, the Act was never officially passed. This brings us back to that gray area; SARMs are to be used for research purposes only and are not suitable for human consumption and anyone marketing it for such a purpose (e.g. in a dietary supplement) risks prosecution. This still makes it available for purchase online as long as it is marketed as a research chemical not to be consumed by humans.  

References

  1. Unwalla, R., Mousseau, J. J., Fadeyi, O. O., Choi, C., Parris, K., Hu, B., Kenney, T., Chippari, S., McNally, C., Vishwanathan, K., Kilbourne, E., Thompson, C., Nagpal, S., Wrobel, J., Yudt, M., Morris, C. A., Powell, D., Gilbert, A. M., & Chekler, E. (2017). Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators. Journal of medicinal chemistry, 60(14), 6451–6457. https://doi.org/10.1021/acs.jmedchem.7b00373
  2. S.2895 – 116th Congress (2019-2020): SARMs Control Act of 2019. (2019, November 19). Congress.gov | Library of Congress. https://www.congress.gov/bill/116th-congress/senate-bill/2895
  3. 21 U.S. code § 812 – Schedules of controlled substances. (n.d.). LII / Legal Information Institute. https://www.law.cornell.edu/uscode/text/21/812

Popular SARMs Info

  • LGD 4033 – Ligandrol
  • Ostarine
  • RAD 140 / RAD140
  • SR9009 Stenabolic
  • YK11 / YK-11
  • GW501516 Cararine
  • MK2866 – Ostarine S22
  • S4 Andarine
  • MK677 Ibutamoren
  • S23
  •  S22
  • We aim to answer Some of the most common Searches related to Sarms and Questions:

What are Sarms?

Are Sarms Safe?

What are the side effects of Sarms?

What is the half life of a Sarm?

Do Sarms make you Stronger?

Do Sarms make you Faster?

Can Sarms be detected in Drug Tests?

Do they test for Sarms?

What is Rad 140

What is mk677

What is S22?

What is Cardarine?

What is LGD 4033?

 

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